Thermal properties of biological tissue gel-phantoms in a wide low-temperature range

It is often impossible or impractical to conduct experiments on cooling, freezing, and thawing during medical cryoexposures with using biological tissues. In such cases, gel-phantoms are used. Due to the lack of accurate data, the definition of the thermal properties of gel-phantoms is relevant. The current study presents the results of the thermal properties measurements with using the differential scanning calorimetry (DSC) and transient hot bridge (THB) methods and of their analysis for five gel-phantoms: 1) 95% water and 5% gelatin; 2) 95% water and 5% agar-agar; 3) 94% water, 3% gelatin, 2.5% agar-agar, and 0.5% sodium chloride; 4 and 5) ultrasound gels. The values of the effective specific heat capacity from –160 to 40o C, thermal conductivity, moisture content, freezable water fraction, and of the initial melting and cryoscopic temperatures are determined. The obtained results are compared with the values of the thermal properties of biotissue and distilled water. The influence of the gelphantom type on the character of phase transition is shown. Adaptation of the experimental data for cryoexposure simulation software is proposed. Recommendations for selecting a phantom are given. The impact of simplification of the thermal properties on the thermal diffusivity is estimated. The data for calculating the properties of phantoms of different composition are proposed.
Автор:  Agafonkina I. V., Belozerov A. G., Berezovsky Yu. M., Korolev Yu. M., Pushkarev A. V., Tsiganov D. I., Shakurov A. V., Zherdev A. A.
Ключевые слова:  thermal properties, gel-phantom, ultrasound gel, agar, gelatin, biological tissue, DSC, THB.
Стр:  811-824