MODEL OF PHOTODYNAMIC THERAPY OF SKIN TUMORS

S. A. Gubarev, A. A. Makhanek, and Z. P. Shul'man

UDC 536.24 + 532.135]:577.344.3

We have constructed a physico-mathematical model
of photodynamic therapy of skin tumors taking into
account the photochemical reactions and the features
of the radiation propagation, the heat and mass transfer,
and the mass transfer of oxygen in the irradiation zone.
The numerical solution has shown that depending on the
light intensity and the degree of injury of exchange
vessels the concentration of oxygen in a tumor can
decrease to below the hypoxic limit, which limits
the photodynamic effect. We have analyzed different
methods of conducting this therapy, thus increasing
its success - changing the radiation intensity
and hyperoxygenation.

A. V. Luikov Heat and Mass Transfer Institute, National
Academy of Sciences of Belarus, 15 P. Brovka Str., Minsk,
220072, Belarus. Translated from Inzhenerno-Fizicheskii
Zhurnal, Vol. 80, No. 1, pp. 76-82, January-February, 2007.
Original article submitted October 10, 2006.