EFFECTS OF THE COMPOSITION OF A NONWETTING LIQUID ON THE KINETICS OF OUTFLOW FROM A NANOPOROUS MATERIAL

The paper presents the results of investigation into the eff ects of the composition of a nonwetting liquid (distilled water, physiological solution, and doxorubicin solution) on the kinetics of outfl ow from hydrophobized Fluka 100 C₁₈ silica gel. A series of measurements was taken regarding the fi lling of and discharge from the investigated systems in the temperature range of 5 to 40^o C with the waiting time between cycles 10–1000 s. Values were obtained for the fraction of the liquid that failed to fl ow out of a porous material as a function of time and temperature, and also the functions of pore size distribution were recovered for the retained liquid. A reduction was found in the fraction of the retained liquid with increase in temperature and the waiting time. It follows from the obtained results that the determination of the outfl ow kinetics for a doxorubicin solution with a concentration of up to 1 μM can be carried out without using a medicinal drug.
The paper presents the results of investigation into the eff ects of the composition of a nonwetting liquid (distilled water, physiological solution, and doxorubicin solution) on the kinetics of outfl ow from hydrophobized Fluka 100 C₁₈ silica gel. A series of measurements was taken regarding the fi lling of and discharge from the investigated systems in the temperature range of 5 to 40^o C with the waiting time between cycles 10–1000 s. Values were obtained for the fraction of the liquid that failed to fl ow out of a porous material as a function of time and temperature, and also the functions of pore size distribution were recovered for the retained liquid. A reduction was found in the fraction of the retained liquid with increase in temperature and the waiting time. It follows from the obtained results that the determination of the outfl ow kinetics for a doxorubicin solution with a concentration of up to 1 μM can be carried out without using a medicinal drug.
Author:  V. D. Asafova, S. A. Kulakov, S. A. Bortnikova, A. A. Belogorlov
Keywords:  nanoporous material, nonwetting liquid, mercury porosimetry, nonwetting liquid relaxation
Page:  1508